freeman
المـديـر العـــام
عدد المساهمات : 19145
تاريخ التسجيل : 05/01/2011
العمر : 64
الموقع : http://sixhats.jimdo.com/
 | موضوع: Sleep Drives Metabolite Clearance from the Adult Brain  الأحد فبراير 02, 2014 6:56 pm | |
| The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.
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لا أحد يظن أن العظماء تعساء إلا العظماء أنفسهم. إدوارد ينج: شاعر إنجليزي
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